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Metformin is a biguanide oral hypoglycemic agent. Metformin does not cause hypoglycemia in nondiabetic subjects and do not stimulate pancreatic beta cells. Actoplus Met is not used in type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. Metformin promotes peripheral glucose utilization by enhancing anerobic glycolysis. It also inhibits intestinal absorption of glucose. Pioglitazone is a thiazolinedione that enhances the transcription of insulin responsive genes. Pioglitazone improves the entry of glucose in to muscles and fats. Pioglitazone suppresses hepatic gluconeogenesis. Actos has glucose sensitizing action due to activation of genes that regulate fatty acid metabolism and lipogenesis in adipose tissue. Pioglitazone reduces blood glucose without increasing circulating insulin. Actoplus Met is now available as generic drug too and you can buy Actoplus Met online from our pharmacy. 

Manufacturer: N/A	Average Delivery Time: 12-21 Business Days
Brand Name: Actoplus Met, Pioglit-MF	Tell a Friend

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Generic Actoplus Met15/500mg Tabs

Quantity	Price	Price Per Pill
90 Tab(s)	$49.00	$0.54		Buy now!

FAQ About Generic Actoplus Met

How does Metformin-Pioglitazone / Generic Actoplus Met work?
Actoplus Met has two components that act in different manners. Metformin suppresses hepatic gluconeogenesis and glucose output from liver. Metformin enhances insulin mediated glucose disposal in muscle and fat. Metformin also enhances GLUT1 transport from intracellular site to plasma membrane. Pioglitazone is a selective agonist of peroxisome proliferator-activated factor γ (PPARγ). PPAR receptors are found in adipose tissue, skeletal muscle and liver. Pioglitazone reverses insulin resistance by stimulating GLUT4 expression and translocation.

Side effects of Actoplus Met
The common side effects reported with Actoplus Met are upper respiratory tract infection, head ache, diarrhea, nausea, urinary tract infection, sinusitis, dizziness, edema in lower limb and increased weight.

Guidelines before using Metformin-Pioglitazone
Actoplus Met should be taken with meals to reduce gastrointestinal side effects of Metformin. Actoplus Met should not be administered in pregnant women and nursing mothers. Metformin-Pioglitazone tablet should be taken as whole without chewing or crushing. The dose of Actoplus Met should be adjusted in patients with decreased renal function, elderly patients and malnourished pateints. Actoplus Met should not be administered in patients with active liver disease. It is advised to avoid alcohol intake while on Metformin-Pioglitazone treatment. It is also advised to perform regular renal and hematological tests. Pioglitazone can cause ovulation in premenpausal anovulatory women. Actoplus Met is contraindicated in patients with class III and IV heart failure. Actoplus Met should not be used in patients receiving intravascular iodine as a part of radiation therapy as it can cause acute alteration of renal function.

What are the common dosages of Generic Actoplus Met?
The recommended starting dosage of Pioglitazone is 15 or 30mg once daily. The recommended starting dosage of Metformin is 850 to 1000mg daily. The dose can be titrated to a maximum of 45mg once daily for Pioglitazone and 2550mg daily for Metformin. The recommended starting dose of Actoplus Met is 15mg/500mg or 15mg/850mg administered once or twice daily.

Difference between Brand and Generic Metformin-Pioglitazone
Brand and generic Actoplus Met contains Metformin-Pioglitazone as the main active ingredients and hence there is no significant difference between the two. The mechanism of action and the effectiveness remain the same in both brand and generic Actoplus Met. The difference between brand and generic forms are packaging, pricing and the brand name. You can buy cheap Actoplus Met online when it is sold as a generic drug.

Where and How to buy Metformin-Pioglitazone / Generic Actoplus Met
You can purchase Actoplus Met medicine online from our pharmacy. Whenyou order Actoplus Met drug online from us, it will reach your doorstep without any hassles. We guarantee cheapest prices when you buy Actoplus Met online from us.

Why is the price of Metformin-Pioglitazone / Generic Actoplus Met so cheap at Aclepsa.com?
In line with Aclpesa.com’s belief of making every drug available at affordable prices, we work continually to identify cost saving measures. Cost saving methods such as direct sourcing and bulk purchase help us sell our products at a cheaper price.