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Irbesartan acts as antihypertensive by preventing the narrowing of blood vessels and improving the blood flow to heart. Angiotensin II has very short half-life and it is acted upon by aminopeptidase to form Angiotensin III, which stimulates aldosterone secretion Hydrochlorothiazide causes a fall in blood pressure over a period of 2 to 4 weeks by decreasing the total peripheral resistance. Hydrochlorothiazides are mild hypertensives and they potentiate the action of other hypertensives and prevent the development of tolerance. Hydrochlorothiazide is more effective in elderly patients. Generic variants are also available and you can buy Avalide online from our pharmacy.

Manufacturer: N/A	Average Delivery Time: 12-21 Business Days
Brand Name: Avalide, Irovel-H	Tell a Friend

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Generic Avalide 150/12.5mg Tabs

FAQ About Generic Avalide

How does Irbesartan- Hydrochlorothiazide / Generic Avalide work?
Hydrochlorothiazide diuretics act by inhibiting the Na+ -Cl- symport at the luminal membrane. Na+ -Cl- symporter is a glycoprotein with 12 membrane-spanning domains. Hydrochlorothiazide exchanges increased amount of sodium with potassium ion and increases potassium ion excretion. Hydrochlorothiazide causes diuresis, which reduces plasma and extracellular fluid (ECF) volume and decreases cardiac output. Irbesartan is an Angiotensin II receptor antagonist that causes vasodilation and decrease blood volume that results in a fall in blood pressure. Angiotensin II receptor antagonist prevents the secretion of Aldosterone that decreases the blood volume.

Side effects of Avalide
The common side effects reported with Irbesartan- Hydrochlorothiazide are fever, chills, orthostatic hypotension, facial edema, flushing, hypertension, pruritis, dermatitis, sexual dysfunction, libido changed, diarrhea, gastroenteritis, flatulence, muscle cramp, stiffness, anxiety, nervousness, numbness, somnolence, cough, upper respiratory tract infections and transient blurred vision.

Guidelines before using Irbesartan- Hydrochlorothiazide
Avalide is not prescribed for patients with severe renal impairment. For patients with severe renal impairment loop a diuretic is the drug of choice. Irbesartan- Hydrochlorothiazide can be taken without regard of food. In patients with volume depletion Avalide is recommended as initial therapy. Avalide when given along with alcohol, narcotics or barbiturates can potentiate orthostatic hypotension. Irbesartan- Hydrochlorothiazide when given along with corticosteroids can cause hypokalemia. Avalide when given with lithium can cause lithium toxicity. The concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and Avalide can cause a decrease in the diuretic effect of Hydrochlorothiazide.

What are the common dosages of Generic Avalide?
The recommended starting dosage of Avalide is 150/12.5 mg/day, administered with or without food. The maximum dose given is 300/25mg once daily. The dose increment can be done after a period of 1 to 2 weeks.

Difference between Brand and Generic Irbesartan- Hydrochlorothiazide
Brand and generic Avalide contains Irbesartan and Hydrochlorothiazide as the active ingredients. The difference between brand and generic forms are packaging, pricing and the brand name. Both are the same in terms of effectiveness. You can buy cheap Avalide pills when it is sold as a generic variant.

Where and How to buy Irbesartan- Hydrochlorothiazide / Generic Avalide
You can purchase Avalide medicine online from our pharmacy. When order Avalide drug online from us, it will reach your doorstep without any hassles. You can also save more when you buy Avalide online in more numbers with the volume discounts we offer.

Why is the price of Irbesartan- Hydrochlorothiazide so cheap at Aclepsa.com?
At Aclepsa.com, we are always working out methods to save costs. Our costs towards research and development are zero, since we sell only generic drugs. We source the drugs directly from the manufacturers and also order in bulk volume. All the savings from the various methods adopted translate to cheap prices of our drugs.

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