Availability: In Stock

Glyburide is sulfonyl urea and Metformin is a biguanide oral hypoglycemic agent. Glyburide causes insulin secretion at any glucose concentration level. Glucovance primarily augments the second phase of insulin secretion with little effect on the first one. Glyburide is highly bound to plasma proteins and has low volume of distribution. Metformin does not cause hypoglycemia in non-diabetic subjects and does not stimulate pancreatic beta cells. Metformin promotes peripheral glucose utilization by enhancing anaerobic glycolysis and also inhibits intestinal absorption of glucose. The incidence of lactic acidosis is rare with Metformin. Together with the two components, Glucovance serves as an effective medication in type 2 diabetes mellitus. You can buy Glucovance online from our pharmacy without any hassles.

Manufacturer: USV	Average Delivery Time: 12-21 Business Days
Brand Name: Glucovance	Tell a Friend

100% Price match guaranteed

We offer the best prices on the net. If you find a website with better pricing, we will match that and give you another 5% off! Learn More

Generic Glucovance 5/500mg

FAQ About Generic Glucovance

How does Glyburide-Metformin / Generic Glucovance work?
Glyburide acts on sulfonyl urea receptor on pancreatic beta cell membrane. This causes depolarization by reducing the conductance of ATP sensitive potassium channels. This in turn increases the calcium influx and insulin release. Metformin suppresses hepatic gluconeogenesis and glucose output from liver. Metformin enhances insulin mediated glucose disposal in muscle and fat. Metformin also enhances GLUT1 transport from intracellular site to plasma membrane. The actions of the two main active ingredients of Glucovance helps in treating diabetes mellitus of type 2 category.

Side effects of Glucovance
The common side effects reported with Glucovance are upper respiratory tract infection, diarrhea, head ache, nausea, vomiting, abdominal pain and dizziness.

Guidelines before using Glyburide-Metformin
Glucovance should be taken with meals to reduce gastrointestinal side effects of Metformin and hypoglycemia of Glyburide. Glucovance is not recommended during pregnancy. Glyburide-Metformin should not be administered along with cationic drugs as it can affect renal function. Glucovance can cause precipitate hypoglycemia. Glucovance should not be used in patients receiving intravascular iodine as a part of radiation therapy as it can cause acute alteration of renal function. Glucovance can cause lactic acidosis leading to hypoxic states and impairment of renal function. It is advised to avoid alcohol intake while on Glyburide-Metformin treatment as alcohol potentiates lactic acidosis. Glucovance is not recommended in patients with active hepatic disease. Glyburide-Metformin is contraindicated in patients with renal disease and acute or chronic metabolic acidosis.

What are the common dosages of Generic Glucovance?
The recommended starting dosage of Glucovance is 1.25mg/250mg taken once or twice daily administered with food. The maximum tolerated dose of Glucovance is 20mg of Glyburide and 2000mg of metformin daily. The titration of dose should be done slowly by monitoring the blood glucose levels of the patient.

Difference between Brand and Generic Glyburide-Metformin
Brand and generic Glucovance contains Glyburide and Metformin as the active ingredients. Therefore the mechanism of action and effectiveness is same for both generic and brand forms. The difference between brand and generic forms are packaging, pricing and the brand name. You can buy cheap Glucovance pills when it is sold as a generic variant.

Where and How to buy Glyburide-Metformin / Generic Glucovance
You can purchase Glucovance medicine online from our pharmacy. When you order Glucovance drug online from us, it will reach your doorstep without any hassles. You can also save more when you buy Glucovance online in more numbers with the volume discounts we offer.

Why is the price of Glyburide-Metformin / Generic Glucovance so cheap at Aclepsa.com?
At Aclepsa.com, we are always working out methods to save costs. Our costs towards research and development are zero, since we sell only generic drugs. We source the drugs directly from the manufacturers and also order in bulk volume. All the savings from the various methods adopted translate to cheap prices of our drugs.